|  联系我们
  1. 首页 > 科研队伍 > 研究团队 > 衰老与再生研究组 > 代表性产出
代表性产出

代表论著：

  1. Lei J, Xin Z, Liu N, Ning T, Jing Y, QiaoY, He Z, Jiang M, Yang Y, Zhang Z, Zhao L, Li J, Lv D, Yan Y, Zhang H, Xiao L, Zhang B, Huang H, Sun S, Zheng F, Jiang X, Lu H, Dong X, Yue S, Ma C, Shuai J, Ji Z, Liu F, Ye Y, Yan K, Hu Q, Xu G, Zhao Q, Wu R, Cai Y, Fan Y, Jing Y, Wang Q, Reddy P, Lu X, Zheng Z, Liu B, Haghani A, Ma S, Suzuki K, Rodriguez Esteban C, Yang J, Song M, Horvath S, Zhang W, Li W, Xiang AP, Zhu L, Fu X, Zhao G, Izpisua Belmonte JC, Qu J, Wang S, Liu GH. Senescence-resistant human mesenchymal progenitor cells counter aging in primates. Cell. 2025.188(18):5039-5061.
  2. Geng L, Ping J, Wu R, Yan H, Zhang H, Zhuang Y, Ning T, Wang J, Liang C, Zhang J, Chu Q, Zhang J, Wen Y, Jing Y, Sun S, Qiao Q, Zhao Q, Ji Q, Ma S, Cai Y, Zheng Y, Zou Z, Diao Z, Li M, Zhang H, Hu J, Fu L, Kang W, Bai R, Zhao H, Zhang S, Ding Y, Lei J, Wang W, Ji Y, Gou B, Sun G, Yin J, Yan P, Li H, Wang Z, Ma S, Liu Z, Shan H, Wang Q, Cao T, Yang S, Wang C, Yang P, Fan Y, Ye Y, Hu J, Jiang M, Wang Y, Liu K, Li Y, Li Y, Li J, Ci W, Jin ZB, Fu X, Zhang X, Zhao G, Izpisua Belmonte JC, Wang S, Song M, Zhang W, Qu J, Liu GH. Systematic profiling reveals betaine as an exercise mimetic for geroprotection. Cell. 2025. 188(19):5426-5428.
  3. Ding Y, Zuo Y, Zhang B, Fan Y, Xu G, Cheng Z, Ma S, Fang S, Tian A, Gao D, Xu X, Wang Q, Jing Y, Jiang M, Xiong M, Li J, Han Z, Sun S, Wang S, He F, Yang J, Qu J, Zhang W, Liu GH. Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures. Cell. 2025. 188(20): 5763-5784.
  4. Jing Y, Lu H, Li J, He Z, Zhao L, Zhang C, Huang Z, Liu L, Sun S, Ma S, Rodriguez Esteban C, Fu X, Zhao G, Izpisua Belmonte JC, Zhang W, Qu J, Wang S, Liu GH. Vitamin C conveys geroprotection on primate ovaries. Cell Stem Cell. 2025. 32(11). 1723-1740.
  5. Sun X, Che S, Wang H, Fan Y, Ding Y, Tan A, Yang K, Hu J, Zhang Y, Ma M, Hu J, Sun S, Li J, Ma S, Wang S, Izpisua Belmonte JC, Qu J, Zhang W, Liu GH. Vascular organoid model of Hutchinson Gilford Progeria Syndrome uncovers repression of the SRF pathway in premature aging. Developmental Cell. 2025. Doi: 10.1016/j.devcel.2025.10.019.
  6. Zhao Q, Jing Y, Jiang X, Zhang X, Liu F, Huang H, Zhang Z, Wang H, Sun S, Ma S, Zhang W, Yu Y, Fu X, Zhao G, Qu J, Wang S, Liu GH. SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1. Nature Metabolism. 2025. 7(3):556-573.
  7. Sun G, Fu X, Zheng Y, Hong G, Liu Z, Luo B, Lei J, Lv D, Chang M, Xiao Y, Guo S, Ma S, Lu L, Zhang W, Belmonte JCI, Qu J, Wang S, Chai R, Liu GH. Single-cell profiling identifies hair cell SLC35F1 deficiency as a signature of primate cochlear aging. Nature Aging. 2025. 5(9):1862-1879.
  8. Sun G, He Z, Lv D, Wang Q, Xu G, Liu F, Wang P, Luo B, Zheng Y, Hu J, Sun S, Ma S, Rodriguez Esteban C, Yang J, Fu X, Belmonte JCI, Zhang W, Qu J, Wang S, Liu GH. Reprogramming the GRHL2-CDK19 axis by gene therapy alleviates prostate aging. Nature Aging. 2025. doi.org/10.1038/s43587-025-01020-y.
  9. Sun G, Li K, Ping J, Zhao L, Cui C, Wu J, Xie L, Yao X, Xu G, Ma S, Fan Y, Wang Q, Yang D, Luo B, Liu H, Yang J, Zhang W, Song W, Zhao G, Fu X, Bian XW, Qu J, Wang S, Chen H, Liu GH. A single-cell transcriptomic atlas reveals senescence and inflammation in the post-tuberculosis human lung. Nature Microbiology. 2025. 10(8):2073-2091.
  10. Yang Y, Lu X, Liu N, Ma S, Zhang H, Zhang Z, Yang K, Jiang M, Zheng Z, Qiao Y, Hu Q, Huang Y, Zhang Y, Xiong M, Liu L, Jiang X, Reddy P, Dong X, Xu F, Wang Q, Zhao Q, Lei J, Sun S, Jing Y, Li J, Cai Y, Fan Y, Yan K, Jing Y, Haghani A, Xing M, Zhu G, Song W, Horvath S, Esteban CR, Song M, Wang S, Zhao G, Li W, Izpisua Belmonte JC, Qu J, Zhang W, Liu GH. Metformin Decelerates Aging Clock in Male Monkeys. Cell. 2024. 187(22):6358-6378.
  11. Ma S, Ji Z, Zhang B, Geng L, Cai Y, Nie C, Li J, Zuo Y, Sun Y, Xu G, Liu B, Ai J, Liu F, Zhao L, Zhang J, Zhang H, Sun S, Huang H, Zhang Y, Ye Y, Fan Y, Zheng F, Hu J, Zhang B, Li J, Feng X, Zhang F, Zhuang Y, Li T, Yu Y, Bao Z, Pan S, Esteban CR, Liu Z, Deng H, Wen F, Song M, Wang S, Zhu G, Yang J, Jiang T, Song W, Belmonte JCI, Qu J, Zhang W, Gu Y, Liu GH. Spatial Transcriptomic Landscape Unveils Immunoglobin-associated Senescence as a Hallmark of Aging. Cell. 2024. 187(24):7025-7044.
  12. Li HY, Wang M, Jiang X, Jing Y, Wu Z, He Y, Yan K, Sun S, Ma S, Wang S, Belmonte JCB, Qu J, Zhang W, Wei T, Liu GH. CRISPR screening uncovers nucleolar RPL22 as a heterochromatin destabilizer and senescence driver. Nucleic Acids Research. 2024. 52(19):11481-11499.
  13. Sun S, Li J, Wang S, Li J, Ren J, Bao Z, Sun L, Ma X, Zheng F, Ma S, Sun L, Wang M, Yu Y, Ma M, Wang Q, Chen Z, Ma H, Wang X, Wu Z, Zhang H, Yan K, Yang Y, Zhang Y, Zhang S, Lei J, Teng ZQ, Liu CM, Bai G, Wang YJ, Li J, Wang X, Zhao G, Jiang T, Belmonte JCI, Qu J, Zhang W, Liu GH. CHIT1-positive microglia drive motor neuron ageing in the primate spinal cord. Nature. 2023. 624(7992):611-620.
  14. Liu X, Liu Z, Wu Z, Ren J, Fan Y, Sun L, Cao G, Niu Y, Zhang B, Ji Q, Jiang X, Wang C,  Wang Q, Ji Z, Li L, Esteban CR, Yan K, Li W, Cai Y, Wang S, Zheng A, Zhang YE, Tan S, Cai Y, Song M, Lu F, Tang F, Ji W, Zhou Q, Belmonte JCI, Zhang W, Qu J, Liu GH. Resurrection of endogenous retroviruses during aging reinforces senescence. Cell. 2023. 186(2):287-304.
  15. Cai Y, Xiong M, Xin Z, Liu C, Jie R，Yang X, Lei J, Li W, Liu F, Chu Q, Yin J, Ye Y, Liu D, Fan Y, Sun S, Zhao Q, Zhao L, Che S, Zheng Y, Yan H, Ma S, Wang S, Belmonte JCI, Qu J, Zhang W, Liu GH. Decoding aging-dependent regenerative decline across tissues at single-cell resolution. Cell Stem Cell. 2023. 30(12):1674-1691.
  16. Ye Y, Yang K, Liu H, Yu Y, Song M, Huang D, Lei J, Zhang Y, Liu Z, Chu Q, Fan Y, Zhang S, Jing Y, Esteban CR, Wang S, Belmonte JCI, Qu J, Zhang W, Liu GH. SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B. Nature Aging. 2023. 3(10):1269-1287.
  17. Wu Z, Lu M, Liu D, Shi Y, Ren J, Wang S, Jing Y, Zhang S, Zhao Q, Li H, Yu Z, Liu Z, Bi S, Wei T, Yang Y, Xiao J, Belmonte JCI, Qu J, Zhang W, Ci W, Liu GH. M6A epitranscriptomic regulation of tissue homeostasis during primate aging. Nature Aging. 2023. 3(6):705-721.
  18. Li J, Xiong M, Fu XH, Fan Y, Dong C, Sun X, Zheng F, Wang SW, Liu L, Xu M, Wang C, Ping J, Che S, Wang Q, Yang K, Zuo Y, Lu X, Zheng Z, Lan T, Wang S, Ma S, Sun S, Zhang B, Chen CS, Cheng KY, Ye J, Qu J, Xue Y, Yang YG, Zhang F, Zhang W, Liu GH. Determining a Multimodal Aging Clock in a Cohort of Chinese Women. Med. 2023. 4(11):825-848.
  19. Ma S, Wang S, Ye Y, Ren J, Chen R, Li W, Li J, Zhao L, Zhao Q, Sun G, Jing Y, Zuo Y, Xiong M, Yang Y, Wang Q, Lei J, Sun S, Long X, Song M, Yu S, Chan P, Wang J, Zhou Q, Belmonte JCI, Qu J, Zhang W, Liu GH. Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues. Cell Stem Cell. 2022. 29(6):990-1005.
  20. Liu Z, Ji Q, Ren J, Yan P, Wu Z, Wang S, Sun L, Wang Z, Li J, Sun G, Liang C, Sun R, Jiang X, Hu J, Ding Y, Wang Q, Bi S, Wei G, Cao G, Zhao G, Wang H, Zhou Q, Belmonte JCI, Qu J, Zhang W, Liu GH. Large-Scale Chromatin Reorganization Reactivates Placenta-Specific Genes that Drive Cellular Aging. Developmental Cell. 2022. 57(11):1347-1368.
  21. Zhao H, Ji Q, Wu Z, Wang S, Ren J, Yan K, Wang Z, Hu J, Chu Q, Hu H, Cai Y, Wang Q, Huang D, Ji Z, Li J, Belmonte JCI, Song M, Zhang W, Qu J, Liu GH. Destabilizing heterochromatin by APOE mediates senescence. Nature Aging. 2022. 2(4):303-316.
  22. Liang C, Ke Q, Liu Z, Ren J, Zhang W, Hu J, Wang Z, Chen H, Xia K, Lai X, Wang Q, Yang K, Li W, Wu Z, Wang C, Yan H, Jiang X, Ji Z, Ma M, Long X, Wang S, Wang H, Sun H, Belmonte JCI, Qu J, Xiang AP, Liu GH. BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates. Nucleic Acids Research. 2022. 50(6):3323-3347.
  23. Kang W, Jin T, Zhang T, Ma S, Yan H, Liu Z, Ji Z, Cai Y, Wang S, Song M, Ren J, Hu B, Zhou Q, Zhang W, Qu J, Bao Y, Liu GH. Regeneration Roadmap: database resources for regenerative biology. Nucleic Acids Research. 2022. 50(D1):D1085-D1090.
  24. Yan H, Wang R, Ma S, Huang D, Wang S, Ren J, Lu C, Chen X, Zhang W, Qu J, Zhou Y, Liu GH. Lineage Landscape: A comprehensive database that records lineage commitment across species. Nucleic Acids Research. 2022. 51(D1):D1061-D1066.
  25. Liu ZP, Li W, Geng L, Sun L, Wang Q, Yu Y, Yan P, Liang C, Ren J, Song M, Zhao Q, Lei J, Cai Y, Li J, Yan K, Wu Z, Chu Q, Li J, Wang S, Li C, Han JD, Hernandez-Benitez R, Shyh-Chang Ng, Izpisua Belmonte JC, Zhang WQ, Qu J, Liu GH. Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor. Cell Discovery. 2022. 1;8(1):6.
  26. Wang W, Zheng Y, Sun S, Li W, Song M, Ji Q, Wu Z, Liu Z, Fan Y, Liu F, Li J, Esteban CR, Wang S, Zhou Q, Belmonte JCI, Zhang W, Qu J, Tang F, Liu GH. A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence. Science Translational Medicine. 2021.13, Jan 6;13(575):eabd2655.
  27. Zou Z, Long X, Zhao Q, Zheng Y, Song M, Ma S, Wang S, He Y, Esteban CR, Huang J, Yu N, Chan P, Belmonte JCI, Zhang W, Qu J, Liu GH. A single-cell transcriptomic atlas of human skin aging. Developmental Cell. 2021. 56(3):383-397.
  28. Liang C, Liu Z, Song M, Li W, Wu Z, Wang Z, Wang Q, Wang S, Yan K, Sun L, Hishida T, Cai Y, Izpisua Belmonte JC, Guillen P, Chan P, Zhou Q, Zhang W, Qu J, Liu GH. Stabilization of Heterochromatin by CLOCK Promotes Stem Cell Rejuvenation and Cartilage Regeneration. Cell Research. 2021. 31(2):187-205.
  29. Aging Atlas Consortium, Zhang W, Qu J, Bao Y, Liu GH. Aging Atlas: a multi-omics database for aging biology. Nucleic Acids Research. 2021. 8;49(D1):D825-D830.
  30. Wang S, Zheng Y, Li J, Yu Y, Zhang W, Song M, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Esteban C, Chan P, Qiao J, Zhou Q, Belmonte JC, Qu J, Tang F, Liu GH. Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. Cell. 2020. 180(3):585-600. 
  31. Ma S, Sun S, Geng L, Song M, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Rodriguez Esteban C, Long X, Guo G, Chan P, Zhou Q, Belmonte JC, Zhang W, Qu J, Liu GH. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Cell. 2020. 180(5):984-1001. 
  32. Ma S, Sun S, Li J, Fan Y, Qu J, Sun L, Wang S, Zhang Y, Yang S, Liu Z, Wu Z, Zhang S, Wang Q, Zheng A, Duo S, Yu Y, Belmonte JCI, Chan P, Zhou Q, Song M, Zhang W, Liu GH. Single-Cell Transcriptomic Atlas of Primate Cardiopulmonary Aging. Cell Research. 2020. 31(4):415-432.
  33. Yan P, Liu Z, Song M, Wu Z, Xu W, Li K, Ji Q, Wang S, Liu X, Yan K, Esteban CR, Ci W, Izpisua Belmonte JC, Xie W, Ren J, Zhang W, Sun Q, Qu J, Liu GH. Genome-wide R-loop landscapes during cell differentiation and reprogramming. Cell Reports. 2020. 32(1):107870
  34. Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, Ren X, Fu L, Li W, Zhang W, Guillen P, Belmonte J, Chan P, Qu J, Liu GH. Stabilizing Heterochromatin by DGCR8 Alleviates Senescence and Osteoarthritis. Nature Communications. 2019.10(1):3329.
  35. Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Belmonte JC, Chan P, Qu J, Tang F, Liu GH. Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis. PLoS Biology. 2019. 17(4):e3000201.
  36. Ren X, Hu B, Song M, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren R, Ding J, Chan P, Jiang C, Ye K, Qu J, Tang F, Liu GH. Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis. Cell Reports. 2019. 26(13):3643-3656.
  37. Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, Ren R, He X, Wang S, Ding J, Chan P, Zhang W, Song M, Belmonte JC, Qu J, Tang F, Liu GH. FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. Cell Stem Cell. 2019. 24(3), 447-461.

 

综述或观点：

  1. Biomarkers of ageing of humans and non-human primates. Nature Reviews Molecular Cell Biology. 2025. 26(11):826-847.
  2. The X-Age Project to construct a Chinese aging clock. Nature Aging. 2025. 5(9):1669-1685.
  3. Aging and immunity. Immunity. 2025. 58(11). 2609-2612.
  4. Exploring the heterogeneous targets of metabolic aging at single-cell resolution. Trends in Endocrinology & Metabolism. 2025. 36(2):133-146.
  5. Insights and Interventions in Age-Associated Inflammation. Current Opinion in Genetics and Development. 2025. 91:102306.
  6. Metabolic heterogeneity in humans. Cell. 2024. 187(15):3821-3823.
  7. Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases. Nature Reviews Molecular Cell Biology. 2024. 25(12):979-1000.
  8. Stress, epigenetics, and aging: unraveling the intricate crosstalk. Molecular Cell. 2024. 84(1):34-54.
  9. Perspectives on biomarkers of reproductive aging for fertility and beyond. Nature Aging. 2024. 4(12):1697-1710.
  10. Targeting aging and age-related diseases with vaccines. Nature Aging. 2024. 4(4):464-482.
  11. Emerging epigenetic insights into aging mechanisms and interventions. Trends in Pharmacological Sciences. 2024. 45(2):157-172.
  12. The Aging Biomarker Consortium represents a new era for aging research in China. Nature Medicine. 2023. 29(9):2162-2165.
  13. Endogenous retroviruses in development and health. Trends in Microbiology. 2023. 32(4):342-354.
  14. Acting on ethics and governance of aging research. Trends in Molecular Medicine. 2023. 29(6):419-421.
  15. Decoding Aging Hallmarks at the Single-Cell Level. Annual Review of Biomedical Data Science. 2023. 10:6:129-152.
  16. Biomarkers of aging. Science China Life Science. 2023. 66(5):893-1066.
  17. Q&A with Guang-Hui Liu. Cell Reports. 2023. 42(8):112862.
  18. Deciphering RNA m6A regulation in aging: Perspectives on current advances and future directions. Aging Cell. 2023. 22(10):e13972.
  19. Hepatocyte reprogramming in liver regeneration: biological mechanisms and applications. The FEBS Journal. 2023. 290(24):5674-5688.
  20. Longevity secret - a pluripotent superpower. Cell Metabolism. 2022. 34(6):803-804.
  21. Voicing the story behind the cover. Developmental Cell. 2022. 57(24):2679-2682.
  22. A Stem Cell Aging Framework, from Mechanisms to Interventions. Cell Reports. 2022. 41(3):111451.
  23. The landscape of aging. Science China Life Science. 2022. 2:1-101.
  24. Opening up the black box of human cell plasticity. Innovation. 2022. 3(5):100276.
  25. Epigenetic regulation of aging: implications for interventions of aging and diseases. Signal Transduction and Targeted Therapy. 2022. 7(1):374.
  26. Genetic Enhancement: an Avenue to Combat Aging-related Diseases. Life Medicine. 2022. 1(3): 307–318.
  27. Rejuvenation of Tissue Stem Cells by Intrinsic and Extrinsic Factors. Stem Cells Translational Medicine.2022. 11(3):231-238.
  28. The ageing epigenome and its rejuvenation. Nature Reviews Molecular Cell Biology. 2020. 21(3):137-150.
  29. Engineering Tissues and Organs: The Road to the Clinic. Cell. 2020. 181(1):22-23.
  30. Single-cell omics in ageing: a young and growing field. Nature Metabolism. 2020. 2(4):293-302.
  31. A β-galactosidase kiss of death for senescent cells. Cell Research. 2020. 30(7):556-557.
  32. Treating Osteoarthritis via Gene Therapy with Rejuvenation Factors. Gene Therapy. 2020. 27(7-8):309-311. 
  33. Age-Related Cardiopathies Gene Editing. Aging. 2019. 11(5):1327-1328.
中国科学院动物研究所 中国科学院大学
科技部 国家自然科学基金委 国家科技管理信息系统公共服务平台 中国动物学会 中国细胞生物学会 中国生理学会
版权所有 © 器官再生与智造全国重点实验室 备案号：京ICP备05064604号
地址：北京市朝阳区大屯路中国科学院动物研究所　邮编：100101　电话：86-010-64807312