代表性产出----器官再生与智造全国重点实验室

代表性产出

Shen, Q.#; Zhang, X.#; Chen, N.#; Yan, X.#; Ren, H.#; Sun, X.; Xu, L.; Zhao, J.; Jia, X.; Yuan, Y.; Li, R.; Lin, S.; Yuan, H.; Li, Y.; Yu, L.*; Wei, Y.* Reconstituting Human Primitive Streak Formation through Extra-Embryonic Cell Coordination. Cell, 2026 (Accepted) (共同通讯/ Co-correspondence)
Li, Q.#; Yuan, Y.#; Zhao, W.; Li, Y.; Shi, J.; Xiu, Y.; Han, M.; Han, Y.; Zhang, J.; Cheng, S.; Qi, X.; Sun, X.; Jia, T.; Xing, J.; Deng, S.; Yan, X.; Oura, S.; Li, H.; Sun, Y.; Yuan, H.; Ma, X.; Xin, M.; Zhao, J.; Zhu, X.; Wang, C.; Wang, Q.; Lin, G.; Yang, X.*; Wei, Y.*; Wu, J.*; Wang, H.*; Yu, L.* A 3D in vitro model for studying human implantation and implantation failure. Cell, 2026. (最后通讯/ Last correspondence)
Tan, J.P.#; Liu, Y.#; Fu, Y.#; Liang, L.#; Wu, Y.#; Guo, T.#; Jia, S.; Jiang, Y.; Yuan, T.; Li, J.; Li, Y.; Huang, Z.; Li, S.; Li, J.; Yan, X.; Liao, Z.; Liu, X.; Hu, B.; Fu, S.; Hao, S.; Tian, L.; Liu, Z.; Yu, L.*; Liu, L.*; Liu, X.* A three-dimensional spatial transcriptome atlas reconstructs early organogenesis in primate Carnegie stages 9 and 10 embryos. Nature Cell Biology, 2026 (共同通讯/ Co-correspondence)
De Los Angeles, A.; Bayne, T.; Benvenisty, N.; Deng, H.; Fujita, M.; Ji, W.; Latham, S.; Li, T.; Liu, P.; Loh, Y.H.; Lunshof, J.; Pei, D.; Pho, N.; Silva, J.C.R.; Ka Ki Tam, T.T.; Tao, T.; Trounson, A.; Xu, S.; Yu, L.; Koplin, J.; Regenberg, A.; Sugaya, K.; Savulescu, J.; Zernicka-Goetz, M.; Lovell-Badge, R. A two-tier framework for responsible research on human embryo models. Cell, 2026. (字母排序)
Arias, A.M.; Rivron, N.; Tajbakhsh, S.; Johnston, J.; Alev, C.; Bally-Cuif, L.; Boke, E.; Cave, E.; Cyranoski, D.; David, L.; Esteban, M.A.; Fu, J.; Geijsen, N.; de Graeff, N.; Hanna, J.H.; Hopwood, N.; Inamdar, M.S.; Lanner, F.; Leeners, B.; Liu, Z.; Jean Leon, M.; Minchiotti, G.; Moris, N.; Munsie, M.; Niakan, K.K.; Pourquie, O.; Pasque, V.; Pera, M.; Peng, Y.; Petropoulos, S.; Ramanathan, S.; Rossant, J.; Rugg-Gunn, P.; Saitou, M.; Sermon, K.; Silva, J.; Theunissen, T.; Turco, M.; Wallingford, J.; Wang, H.; Warmflash, A.; Wu, J.; Yu, L. Human stem cell-based embryo models: innovation, ethics, and policy. Human Reproduction, 2026. (字母排序)
Gao, L.#; Gao, Q.#; Hai, N.#; Wu, Z.#; Li, P.#; Kang, H.; Song, X.; Hua, J.; Zhang, S.; Ren, G.; Yang, J.; Yu, L.*; Wei, Y.*; Ding, J.*; Yang, F.* Phase separation of DUX family proteins drives totipotent-like state via 3D genome reorganization and retrotransposon activation. Protein & Cell, 2026. (共同通讯/ Co-correspondence)
Guo, J.#; Lyu, J.#; Gao, Z.#; Jia, T.#; Wang, L.#; Dong, J.; Gu, Z.; Ji, S.; Li, W.; Wang, H.; Zhai, J.*; Yu, L.*; Feng, G.*; Zhou, Q.*; Gu, Q.* 3D biomimetic niche niche embryo development in vitro. Nature Communications, 2026. (共同通讯/ Co-correspondence)
Yuan, Y.#; Wang, X.#; Yan, X.#; He, N.#; Lu, X.#; Yang, J.#; Xie, X.#; Yuan, H.; Chen, N.; Liu, Y.; Ren, H.; Zhang, R.; Cui, L.; Ren, P.; Lin, S.; Cheng, S.; Yang, X.; Guo, Y.; Li, R.; Yan, T.; Guo, J.*; Xiao, Z.*; Wei, Y.*; Yu, L.* 3D reconstruction of a human Carnegie stage 9 embryo provides a snapshot of early body plan formation. Cell Stem Cell, 2025. (最后通讯/ Last correspondence)
Ni, C.#; Wei, Y.#; Vona, B.#; Park, D.; Wei, Y.; Schmitz, D.A.; Ding, Y.; Sakurai, M.; Ballard, E.; Li, L.; Liu, Y.; Kumar, A.; Xing, C.; Qin, S.; Kim, S.; Fogliazzo, M.; Zhao, J.; Kim, H.G.; Ekmekci, C.; Karimiani, E.G.; Imannezhad, S.; Eghbal, F.; Badv, R.S.; Schwaibold, E.M.C.; Dehghani, M.; Mehrjardi, M.Y.V.; Metanat, Z.; Eslamiyeh, H.; Khouj, E.; Alhajj, S.M.N.; Chedrawi, A.; Ramzan, K.; Hashmi, J.A.; Alluqmani, M.M.; Basit, S.; Veltra, D.; Marinakis, N.M.; Niotakis, G.; Vorgia, P.; Sofocleous, C.; Lee, H.; Jeong, W.C.; Umair, M.; Bilal, M.; Alves, C.A.P.F.; Sieber, M.; Kruer, M.; Houlden, H.; Alkuraya, F.S.; Cenik, C.; Yu, L.*; Maroofian, R.*; Wu, J.*; Buszczak, M.* A programmed decline in ribosome levels governs human early neurodevelopment. Nature Cell Biology, 2025. (共同通讯/ Co-correspondence)
Cui, L.#; Lin, S.#; Yang, X.#; Xie, X.#; Wang, X.; He, N.; Yang, J.; Zhang, X.; Lu, X.; Yan, X.; Guo, Y.; Zhang, B.; Li, R.; Miao, H.; Ji, M.; Zhang, R.; Yu, L.*; Xiao, Z.*; Wei, Y.*; Guo, J.* Spatial transcriptomic characterization of a Carnegie stage 7 human embryo. Nature Cell Biology, 2025. (共同通讯/ Co-correspondence)
Ren, H.#; Jia, X.#; Yu, L.*, The building blocks of embryo models: embryonic and extraembryonic stem cells. Cell Discovery, 2025. (最后通讯/ Last correspondence)
De Los Angeles, A.; Benvenisty, N.; Deng, H.; Hanna, J.H.; Koplin, J.; Li, T.; Liu, P.; Loh, Y.H.; Pei, D.; Sugimura, R.; Tam, T.T.K.K.; Tao, T.; Trounson, A.; Xu, S.; Yu, L.; Zambidis, E.; Zernicka-Goetz, M.; Lovell-Badge, R. Human embryo research: how to move towards a 28-day limit. Nature, 2025. (字母排序)
Wu, Z.#; Ren, H.#; Yu, L.* Building the start: Unlocking advanced stem cell-based embryo models. Cell Stem Cell, 2025. (最后通讯/ Last correspondence)
Xiao, Z.#; Cui, L.#; Yuan, Y.#; He, N.#; Xie, X.; Lin, S.; Yang, X.; Zhang, X.; Shi, P.; Wei, Z.; Li, Y.; Wang, H.; Wang, X.; Wei, Y.; Guo, J.; Yu, L.* 3D reconstruction of a gastrulating human embryo. Cell, 2024. (最后通讯/ Last correspondence)
Pinzon-Arteaga, C.A.; Yu, L.* From clones to synthetic embryos. Life Medicine, 2024. (最后通讯/ Last correspondence)
Wei, Y.#*; Zhang, E.#; Yu, L.#; Ci, B.#; Sakurai, M.; Guo, L.; Zhang, X.; Lin, S.; Takii, S.; Liu, L.; Liu, J.; Schmitz, D.A.; Su, T.; Zhang, J.; Shen, Q.; Ding, Y.; Zhan, L.; Sun, H.X.; Zheng, C.; Xu, L.; Okamura, D.; Ji, W.; Tan, T.; Wu, J.*. Dissecting embryonic and extraembryonic lineage crosstalk with stem cell co-culture. Cell, 2023. (共同一作/ Co-first authors)
Wu, X.#; Zhao, W.#; Wu, H.#; Zhang, Q.#; Wang, Y.; Yu, K.; Zhai, J.; Mo, F.; Wang, M.; Li, S.; Zhu, X.; Liang, X.; Hu, B.; Liu, G.H.; Wu, J.; Wang, H.; Guo, F.*; Yu, L.* An aggregation of human embryonic and trophoblast stem cells reveals the role of trophectoderm on epiblast differentiation. Cell Proliferation, 2023. (最后通讯/ Last correspondence)
Yu, L.#; Logsdon, D.#; Pinzon-Arteaga, C.A.#; Duan, J.#; Ezashi, T.#; Wei, Y.#; Ribeiro Orsi, A.E.; Oura, S.; Liu, L.; Wang, L.; Liu, K.; Ding, X.; Zhan, L.; Zhang, J.; Nahar, A.; Stobbe, C.; Katz-Jaffe, M.; Schoolcraft, W.B.; Tan, T.; Hon, G.C.*; Yuan, Y.*; Wu, J.* Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk. Cell Stem Cell, 2023. (第一作者/ First author)
Yu, L.#; Wei, Y.#; Duan, J.#; Schmitz, D.A.; Sakurai, M.; Wang, L.; Wang, K.; Zhao, S.; Hon, G.C.*; Wu, J.* Blastocyst-like structures generated from human pluripotent stem cells. Nature, 2021. (第一作者/ First author)
Yu, L.#; Wei, Y.#; Sun, H.X.#; Mahdi, A.K.; Pinzon Arteaga, C.A.; Sakurai, M.; Schmitz, D.A.; Zheng, C.; Ballard, E.D.; Li, J.; Tanaka, N.; Kohara, A.; Okamura, D.; Mutto, A.A.; Gu, Y.; Ross, P.J.; Wu, J.* Derivation of intermediate pluripotent stem cells amenable to primordial germ cell specification. Cell Stem Cell, 2021. (第一作者/ First author)
Liu, T.#; Li, J.#; Yu, L.#; Sun, H.X.; Li, J.; Dong, G.; Hu, Y.; Li, Y.; Shen, Y.; Wu, J.*; Gu, Y.* Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans. Cell Discovery, 2021. (共同一作/ Co-first authors)
Zhang, J.#; Qi, X.#; Zhao, W.; Yuan, S.; Hai, N.; Yu, L.; Hua, J.; Yu, D.*; Wei, Y.* Depicting the dynamic transcriptional and epigenetic landscape of testis development in pubertal Simmental cattle. Journal of Animal Science and Biotechnology, 2026, 17(1): 96.
Schmitz, D.A.; Oura, S.; Li, L.; Ding, Y.; Dahiya, R.; Ballard, E.; Pinzon-Arteaga, C.A.; Sakurai, M.; Okamura, D.; Yu, L.; Ly, P.; Wu, J.* Unraveling mitochondrial influence on mammalian pluripotency via enforced mitophagy. Cell, 2025, 188(17): 4773–4789.e22.
Pinzon-Arteaga, C.A.#; Wang, Y.#; Wei, Y.#; Ribeiro Orsi, A.E.; Li, L.; Scatolin, G.; Liu, L.; Sakurai, M.; Ye, J.; Hao, M.; Yu, L.; Li, B.; Jiang, Z.*; Wu, J.* Bovine blastocyst-like structures derived from stem cell cultures. Cell Stem Cell, 2023, 30(5): 611–616.e7.
Zheng, C.#; Hu, Y.#; Sakurai, M.#; Pinzon-Arteaga, C.A.; Li, J.; Wei, Y.; Okamura, D.; Ravaux, B.; Barlow, H.R.; Yu, L.; Sun, H.X.; Chen, E.H.; Gu, Y.; Wu, J*. Cell competition constitutes a barrier for interspecies chimerism. Nature, 2021, 592(7853): 272–276.
Wang, R.; Qi, Y.; Liu, J.; Li, Y.; An, H.; Wang, H.; Song, J.; Hu, W.; Wu, S.; Yu, L.; Chen, Y.*; Xue, X.* Metal-organic polyhedra maintain the self-renewal of embryonic stem cells. Nature Communications, 2025, 16(1): 8684.
Guo, F.#; He, C.F.#; Xu, Y.H.#; Wu, H.H.#; Li, D.M.#; Jiang, S.Y.#; Ma, X.S.; Huang, C.; Gu, Q.; Du, P.; Yu, L.; Feng, G.H.*; Wang, H.M.*; Li, W.*; Li, X.* High-efficiency generation of blastoids with gastrulation potential through Gata4-induced PrE specification in mESCs. Cell Discovery, 2025, 11(1): 94.
Luo, Y.; Luo, L.; Wang, L.; Yang, S.; Ren, H.; Liang, S.; Wang, X.; Su, Y.; Yu, L.; Wang, X.*; Xu, M.*; Yao, R.* Large-scale bioprinting of human epiblast-like models featuring disc-shaped morphogenesis and gastrulation events. Advanced Science, 2025, 12(33): e05340.
Luo, Q.; Pui, H.P.; Chen, J.; Yu, L.; Jannik, P.R.; Pei, Y.; Zhao, L.; Chen, X.; Petropoulos, S.; Ruas, J.L.; Wu, J.; Deng, Q.* Epiblast-like stem cells established by Wnt/beta-catenin signaling manifest distinct features of formative pluripotency and germline competence. Cell Reports, 2023, 42(1): 112021.
Wang, Y.; Ming, H.; Yu, L.; Li, J.; Zhu, L.; Sun, H.X.; Pinzon-Arteaga, C.A.; Wu, J.*; Jiang, Z.* Establishment of bovine trophoblast stem cells. Cell Reports, 2023, 42(5): 112439.
Sivakumar, S.#; Wang, Y.#; Goetsch, S.C.; Pandit, V.; Wang, L.; Zhao, H.; Sundarrajan, A.; Armendariz, D.; Takeuchi, C.; Deng, M.; Nzima, M.; Chen, W.C.; Dederich, A.E.; El Hayek, L.; Gao, T.; Gogate, A.; Kaur, K.; Kim, H.B.; McCoy, M.K.; Niederstrasser, H.; Oura, S.; Pinzon-Arteaga, C.A.; Sanghvi, M.; Schmitz, D.A.; Yu, L.; Zhang, Y.; Zhou, Q.; Kraus, W.L.; Xu, L.; Wu, J.; Posner, B.A.; Chahrour, M.H.; Hon, G.C.*; Munshi, N.V.* Benchmarking and optimizing Perturb-seq in differentiating human pluripotent stem cells. Stem Cell Reports, 2025, 20(12): 102713.
Schmitz, D.A.#; Okamura, D.#*; Sakurai, M.; Ding, Y.; Oura, S.; Ballard, E.; Wei, Y.; Yu, L.; Hu, Y.; Wu, J.* Dissecting Oct4 enhancer function in pluripotent stem cells and mouse embryogenesis. Stem Cell Reports, 2025, 20(12): 102706.