代表性产出

1. Li, Q.#; Yuan, Y.#; Zhao, W.#; Li, Y.#; Shi, J.#; Xiu, Y.#; Han, M.#; Han, Y.; Zhang, J.; Cheng, S.; Qi, X.; Sun, X.; Jia, T.; Xing, J.; Deng, S.; Yan, X.; Oura, S.; Li, H.; Sun, Y.; Yuan, H.;Ma, X.; Xin, M.; Zhao, J.; Zhu, X.; Wang, C.; Wang, Q.; Lin, G.; Yang, X.*; Wei, Y.*; Wu, J.*; Wang, H.*; Yu, L.* A 3D in vitro model for studying human implantation and implantation failure. Cell, 2025 (最后通讯)

2. Xiao, Z.#; Cui, L.#; Yuan, Y.#; He, N.#; Xie, X.; Lin, S.; Yang, X.; Zhang, X.; Shi, P.; Wei, Z.; Li,Y.; Wang, H.; Wang, X.*; Wei, Y. *; Guo, J.*; Yu, L.*, 3D Reconstruction of a Gastrulating Human Embryo, Cell, 2024 (最后通讯)

  1. 该工作入选Cell 2024年最佳文章“Best of Cell 2024”

3. Yuan, Y. #; Wang, X. #; Yan, X. #; He, N. #; Lu, X. #; Yang, J. #; Xie, X. #; Yuan, H.; Chen, N.; Liu, Y.; Ren, H.; Zhang, R.; Cui, L.; Ren, P.; Lin, S.; Cheng, S.; Yang, X.; Guo, Y.; Li, R.; Yan, T.; Guo, J.*; Xiao, Z.*; Wei, Y.*; Yu, L.*, 3D reconstruction of a human Carnegie stage 9 embryo provides a snapshot of early body plan formation. Cell Stem Cell, 2025a (最后通讯)

4. Wu, Z.; Ren, H.; Yu, L.*, Building the Start: Unlocking Advanced Stem Cell–Based Embryo. Cell Stem Cell, 2025b (最后通讯)

5. Ni, C.; Wei, Y.; Vona, B.; et al.; Yu, L.*; Maroofian, R.*; Wu, J.*; Buszczak, M.*, A programmed decline in ribosome levels governs human early neurodevelopment. Nature Cell Biology, 2025a (共同通讯)

6. Cui, L. #; Lin, S. #; Yang, X. #; Xie, X. #; Wang, X. #; He, N. #; Yang, J.; Zhang, X.; Lu, X.;  Yan, X.; Guo, Y.; Zhang, B.; Li, R.; Miao, H.; Ji, M.; Zhang, R.; Yu, L.*; Xiao, Z. *; Wei, Y.*; Guo, J.*, Spatial transcriptomic characterization of a Carnegie stage 7 human embryo, Nature Cell Biology, 2025b (共同通讯)

7. Yu, L.#; Logsdon, D. #; Pinzon-Arteaga, C.A. #; Duan, J. #; Ezashi, T. #; Wei, Y. #; Oura, S.; Liu, L.; Wang, L.; Liu, K.; Ding, X.; Zhan, L.; Zhang, J.; Nahar, A.; Stobbe, C.; Katz-Jaffe, M.; Schoolcraft, W.B.; Tan, T.; Hon, G.C. *; Yuan, Y. *; Wu, J. *, Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross-talk, Cell Stem Cell, 2023 (第一作者)

8. Yu, L. #; Wei, Y. #; Duan, J. #; Schmitz, D. A.; Sakurai, M.; Wang, L.; Wang, K.; Zhao, S.; Hon, G. C.*; Wu, J.*, Blastocyst-like structures generated from human pluripotent stem cells, Nature, 2021 (第一作者)

  1. 该工作入选Science杂志评选“Sicence 2021年科学10大突破进展”
  2. 该工作入选我国两院院士评选“2021年中国/世界十大科技进展新闻”
  3. 该工作被Natrue杂志(Vol 591, Issue 7851)选为当期封面故事
  4. 当期Nature杂志评论该工作“First complete model of the human embryo”
  5. Nature新闻评论该工作“Lab-grown structures mimic human embryo's earliest stage yet”
  6. Science新闻评论该工作 “Researchers re-create key human embryo stage in lab”
  7. 该工作同时被世界范围600多家媒体机构报道,包括 Xinhua News, NPR News, US News, New York Times, NHK News, Asahi News, NBC News等

9. Wei, Y.#; Zhang, E.#; Yu, L.#; Ci, B.#, Sakurai, M.; Guo, L.; Zhang, X.; Lin, S.; Takii, S.; Liu, L.; Liu, J.; Schmitz, DA.; Su, T.; Zhang, J.; Shen, Q.; Ding, Y.; Zhan, L.; Sun, HX.; Zheng, C.; Xu, L.; Okamura, D.; Ji, W.*; Tan, T.*; Wu, J.*, Dissecting embryonic and extraembryonic lineage crosstalk with stem cell co-culture, Cell, 2023 (共同一作)

10. Ren, H.; Jia, X.; Yu, L.*, Building the Start: Unlocking Advanced Stem Cell–Based Embryo. Cell Discovery, 2025 (最后通讯)

11. Wu, X.#; Zhao, W.#; Wu, H.#; Zhang, Q.#; Wang, Y.; Yu; K.; Zhai, J.; Mo, F.; Wang, M.; Li, S.; Zhu, X.; Liang, X.; Hu, B.; Liu, G. H.; Wu, J.*; Wang, H.*; Guo, F.*; Yu, L.*, An aggregation of human embryonic and trophoblast stem cells reveals the role of trophectoderm on epiblast differentiation, Cell proliferation, 2023 (最后通讯)

12. Pinzón-Arteaga, C.A.; Yu, L.*, From clones to synthetic embryos, Life Medicine, 2024 (最后通讯)

13. Angeles, A.D.L.; Benvenisty, N.; Deng, H.; Hanna, J.; Koplin, J.; Li, T.; Liu, P.; Loh, Y.H.; Pei, D.; Sugimura, R.; Tam, T.T.K.K.; Tao, T.; Trounson, A.; Xu, S.; Yu, L.; Zambidis, E.; Zernicka-Goetz, M.; Lovell-Badge, R.; Human embryo research: how to move towards a 28-day limit, Nature, 2025 (共同评论,首字母排名)

14. Yu, L. #; Wei, Y. #; Sun, H. #; Mahdi, A. K.; Pinzon Arteaga, C. A.; Sakurai, M.; Schmitz, D. A.; Zheng, C.; Ballard, E. D.; Li, J.; Tanaka, N.; Kohara, A.; Okamura, D.; Mutto, A. A.; Gu, Y.; Ross, P. J.; Wu, J.*, Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification, Cell Stem Cell, 2021 (第一作者)

15. Yu, L.; Wei, Y.; Schmitz, D. A.; Sakurai, M.; Wu, J.*, A protocol for the generation of blastocyst-like structures from human pluripotent stem cells, Protocol Exchange, 2021 (第一作者)

16. Liu, T. #; Li, J. #; Yu, L. #; Sun, H.; Li, J.; Dong, G.; Hu, Y.; Li, Y.; Shen, Y.; Wu, J.*; Gu, Y.*, Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans, Cell discovery, 2021 (共同一作)

17. Yu, L. #; Li, J. #; Itsunari, M.; Qu, X.; Miyagawa, S.; Fujimoto, N.; Hasegawa, K.; Chen, Y.; Sawa, Y.; Kotera, H.; Liu, L.*, Clonal Isolation of Human Pluripotent Stem Cells on Nanofibrous Substrates Reveals an Advanced Subclone for Cardiomyocyte Differentiation. Advanced Healthcare Materials, 2019 (第一作者)

18. Yu, L.; Li, J.; Hong, J.; Takashima, Y.; Fujimoto, N.; Nakajima, M.; Dong, X.; Dang, Y.; Yang, W.; Okita, K.; Luo, C.; Tang, F.; Chen, Y.; Tang, C.*; Kotera, H.*; Liu, L.*, Low Cell-Matrix Adhesion Reveals Two Novel Subtypes of Human Pluripotent Stem Cells. Stem Cell Reports, 2018 (第一作者)

19. Li, X.#; Yu, L.#; Li, J.; Minami, I.; Nakajima, M.; Noda, Y.; Kotera, H.; Liu, L.*; Chen, Y.*, On chip purification of hiPSC-derived cardiomyocytes using a fishnet-like microstructure, Biofabrication, 2016 (共同一作)

20. Ballard, E.; Sakurai, M.; Yu, L.; Liu, L.; Oura, S.; Huang, J.; Wu, J., Incompatibility in cell adhesion constitutes a barrier to interspecies chimerism, Cell Stem Cell, 2025 (共同作者)

21. Zheng, C. #; Hu, Y. #; Sakurai, M. #; Pinzon-Arteaga, C. A.; Li, J.; Wei, Y.; Okamura, D.; Ravaux, B.; Barlow, H. R.; Yu, L.; Sun, H.; Chen, E. H.; Gu, Y.; Wu, J.*, Cell competition constitutes a barrier for interspecies chimerism, Nature, 2021 (共同作者)

22. Vilarino, M.; Soto, D.A.; Bogliotti, Y. S.; Yu, L.; Zhang, Y.; Wang, C.; Paulson, E.; Zhong, C.; Jin, C.; Izpisua Belmonte, J. C.; Wu, J.; Ross, P. J.*, Derivation of sheep embryonic stem cells under optimized conditions. Reproduction, 2020 (共同作者)

23. Li, J. #; Zhang, L. #; Yu, L.; Minami, I.; Miyagawa, S.; Hörning, M.; Dong, J.; Qiao, J.; Qu, X.; Hua, Y.; Fujimoto, N.; Shiba, Y.; Zhao, Y.; Tang, F.; Chen, Y.; Sawa, Y.*; Tang, C.*; Liu, L.*, Circulating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring, Communications biology, 2020 (共同作者)

24. Li, R. #; Zhong, C. #; Yu, Y. #; Liu, H.; Sakurai, M.; Yu, L.; Min, Z.; Shi, L.; Wei, Y.; Takahashi, Y.; Liao, H.; Qiao, J.; Deng, H.; Nuñez-Delicado, E.; Rodriguez Esteban, C.; Wu, J. *; Izpisua Belmonte, J. C.*; Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures. Cell, 2019 (共同作者)

25. Zhang, Y.; Li, T.; Preissl, S.; Amaral, M.L.; Grinstein, J.D.; Farah, E.N.; Destici, E.; Qiu, Y.; Hu, R. Lee, A.Y.; Chee, S.; Ma, K.; Ye, Z.; Zhu, Q.; Huang, H.; Fang, R.; Yu, L.; Izpisua Belmonte, J.C.; Wu, J.; Evans, S.M.; Chi, N.C.*; Ren B*. Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells. Nature Genetics, 2019 (共同作者)

26. Xu, J.; Yu, L.; Guo, J.; Xiang, J.; Zheng, Z.; Gao, D.; Shi, B.; Hao, H.; Jiao, D.; Zhong, L.; Wang, Y.; Wu, J.*; Wei, H. *; Han, J*. Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system. Stem Cell Research & Therapy, 2019 (共同作者)

27. Li, J. #; Minami, I. #; Yu, L.; Shiozaki, M.; Shiba, Y.; Yajima, S.; Morone, N.; Fukushima, S.; Yoshioka, M.; Li, S.; Qiao, J.; Li, X.; Wang, L.; Kotera, H.; Miyagawa, S.; Nakatsuji, N.; Sawa, Y.; Chen, Y.; Liu, L., Human Pluripotent Stem Cell-Derived Cardiac Tissue-Like Constructs for Repairing of the Infarcted Myocardium. Stem Cell Reports, 2017 (共同作者)

28. Li, J.; Zhang, F.; Yu, L.; Fujimoto, N.; Yoshioka, M.; Li, X.; Shi, J.; Kotera, H.; Liu, L.* and Chen, Y. * , Culture substrates made of elastomeric micro-tripod arrays for long-term expansion of human pluripotent stem cells, J. Mater. Chem. B, 2017 (共同作者)

29. Tang, Y.; Liu, L.; Li, J.; Yu, L.; Wang, L.; Shi, J.; Chen, Y.*, Induction and Differentiation of Human Induced Pluripotent Stem Cells into Functional Cardiomyocytes on a Compartmented Monolayer of Gelatin Nanofibers. Nanoscale, 2016 (共同作者)

30. Li, J.; Minami, I.; Yu, L.; Tsuji, K.; Nakajima, M.; Qiao, J.; Suzuki, M.; Shimono, K.; Nakatsuji, N.; Kotera, H.; Liu, L.*; Chen, Y.*, Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers. Stem cells international, 2016 (共同作者)

31. Tang, Y.; Liu, L.; Li, J.; Yu, L.; Severino, F. P. U.; Wang, L.; Shi, J.; Tu, X.; Torre, V.; Chen, Y.*, Effective Motor Neuron Differentiation of Hipscs on a Patch Made of Crosslinked Monolayer Gelatin Nanofibers. Journal of Materials Chemistry B, 2016 (共同作者)

发明专利

  1. A Method of Preparing a Pluripotent Stem Cell Suitable for Differentiating into a Cardiomyocyte (国际专利)
  2. Methods for generating formative pluripotent stem cells competent for direct primordial germ cell induction(国际专利)
  3. A common condition for the derivative and culture of embryonic and extra-embryonic stem cells(国际专利)
  4. A method to generate blastocyst-like structure from human pluripotent stem cells(国际专利)