王红梅实验室

王红梅实验室

个人介绍

王红梅,博士,研究员,博士生导师;中国科学院动物研究所副所长。干细胞与生殖生物学国家重点实验室前主任。中国动物学会生殖生物学分会主任委员。英国剑桥大学胎盘研究中心(Loke CTR)学术委员会委员。国家杰出青年基金项目获得者,万人计划领军人才,国家百千万人才工程 “有突出贡献中青年专家”, 国家自然科学基金重大项目、创新研究群体项目负责人,中国科学院战略性科技专项先导课题负责人,国家重点研发计划“基于干细胞的生育力维持与重建”项目负责人。担任Cell Stem Cell 、Dev Cell、Cell Prolif、Cell Rep Med等期刊编委。

1995年于北京师范大学生物系获得学士学位,2002年于中国科学院动物研究所获得理学博士学位,2003-2005年在加拿大渥太华健康研究所从事博士后研究。王红梅课题组研究方向包括:(1)灵长类(人和猴)早期胚胎发育;(2)灵长类胎盘发育;(3)干细胞与生育力的维持和重建。相关工作在Science、Nature、Cell、Nat Genet等期刊发表论文140余篇,被 Science 亮点评述、3 次被 Nature 和 Science 期刊 News 报道、2 次在 Science 和 Cell期刊封面重点介绍,入选Nat Methods年度方法、2023中国生命科学十大进展。在国际干细胞学会、Gordon,Keystone、冷泉港亚洲等国际会议做特邀报告受邀为Trends Cell Biol、Trends Mol Med、Curr Opin Cell Biol、Biol Reprod撰写综述。曾获第十六届谈家桢生命科学创新奖,第五届全国妇幼健康科学技术奖自然科学一等奖,国家人口和计划生育委员会优秀科技成果一等奖等,中国科学院李佩教师奖、优秀导师奖,“朱李月华优秀教师奖”等。培养的研究生多人获国家奖学金、中国科学院院长特别奖等。


发表论文

(Notes: # indicates equal contribution; * indicates corresponding author; ## indicates senior author.)

  1. Clark AT, Cook-Andersen H, Franklin S, Isasi R, Mathews DJH, Pasque V, Rugg-Gunn PJ, Tam PPL, Wang H, Zylicz JJ, Rossant J. Stem cell-based embryo models: The 2021 ISSCR stem cell guidelines revisited. Stem Cell Rep. 2025, 20(6), 102514.

(This Guidelines update underscores the ISSCR's steadfast commitment to proactively addressing the ethical and regulatory considerations that accompany scientific advances)

  1.  Qian Li#, Yang Yuan#, Wentao Zhao#, Yuanjun Li#, Juanzi Shi#, Yu Xiu#, Mi Han#, Junmei Zhang#, Yan Han, Shuhan Cheng, Xin Qi, Xizhuang Sun, Tan Jia, Jiaqi Xing, Siwei Deng, Xiaodi Yan, Seiya Oura, Hongfei Li, Ying Sun, Huiyao Yuan, Xiaohong Ma, Miaomiao Xin, Jianchao Zhao, Xili Zhu, Cong Wang, Qin Wang, Ge Lin, Xiaokui Yang*, Yulei Wei*, Jun Wu*, Wang H*, Leqian Yu*, A 3D In Vitro Model for Studying Human Implantation and Implantation Failures. Cell, 2025 (Acceptance in principle)
  2. Guo Z#, Zhao W#, Wang H##, Zhai J*. (2025). Recent insights into the in vitro culture systems for mammalian embryos. Curr Opin Genet Dev. 2025;91:102309. (Invited Review)
  3. Clark AT*, Goolam M*, Hanna JH*, Long K*, Nicol D*, Petropoulos S*, Saitou M*, Tam PPL*, Wang H*. Human developmental biology - a global perspective. Development. 2024 Sep 1;151(17):dev203092. (Invited Perspective)
  4. Xu Y#, Zhai J#, Wu H#, Wang H*. In vitro culture of cynomolgus monkey embryos from blastocyst to early organogenesis. Nat. Protoc. 2024 Dec;19(12):3677-3696.
  5. Wu H#, Zhai J#, Wang H*. Unraveling the function of FGF signaling in human hypoblast specialization. Cell Stem Cell. 2024, 31(7):945-946. (Invited Comment)
  6. Yan L#, Tu W#, Zhao X#, Wan H#, Wu J#, Zhao Y#, Wu J#, Sun Y#, Zhu L#, Qin Y#, Hu L#, Yang H#, Ke Q#, Zhang W#, Luo W#, Xiao Z#, Chen X#, Wu Q, He B, Teng M, Dai S, Zhai J, Wu H, Yang X*, Guo F*, Wang H*. Stem cell transplantation extends the reproductive life span of naturally aging cynomolgus monkeys. Cell Discov. 2024, 10(1):111.
  7. Yu D#, Luo L#, Wang H*, Shyh-Chang N*. Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses. Trends Endocrinol Metab. 2024, S1043-2760(24)00192-9. (Invited Review)
  8. Yu X#, Wu H#, Su J#, Liu X, Liang K, Li Q, Yu R, Shao X, Wang H*, Wang YL*, Shyh-Chang N*. Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells. Cell Stem Cell. 2024, 31(9):1280-1297.e7.
  9. Wang Y#, Deng W#, Lee D#, Yan L#, Lu Y, Dong S, Huntoon K, Antony A, Li X, Ye R, Zhao Y, Zhao F, Schrank BR, Ha J, Kang M, Yang M, Gong P, Lorenzi PL, Tan L, Gallup TD, Tang SK, Yang Z, Li J, Sanford NN, Wang H*, Kim BYS*, Jiang W*. Age-associated disparity in phagocytic clearance affects the efficacy of cancer nanotherapeutics. Nat Nanotechnol. 2024,19, 255-263.
  10. Yu D#, Wan H#, Tong C#, Guang L#, Chen G#, Su J#, Zhang L, Wang Y, Xiao Z, Zhai J, Ma W, Liang K, Liu T, Wang Y, Peng Z, Luo L, Yu R, Li W*, Qi H*, Wang H*, Shyh-Chang N*. A multi-tissue metabolome atlas reveals core signatures and critical nodes of metabolic reprogramming in female primates during pregnancy. Cell. 2024, 187, 764-781 e714.
  11. Wang M#, Liu Y#, Sun R#, Liu F#, Li J, Yan L, Zhang J, Xie X, Li D, Wang Y, Li S, Zhu X, Li R*, Lu F*, Xiao Z*, Wang H*. Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy. Nat Genet. 2024, 56, 294-305.
  12. Wu X#, Zhai J#, Li Q#, Wang H*. The in vitro culture of mammalian embryos. Nat Method.2023, 20, 1855-1858. (Invited Comment, Selected for Method of the Year 2023: methods for modeling development)
  13. Wu H#, Huang XY#, Sun MX#, Wang Y#, Zhou HY#, Tian Y#, He BJ, Wu AP, Wang H*, Qin CF*. Zika virus targets human trophoblast stem cells and prevents syncytialization in placental trophoblast organoids. Nat Commun. 2023, 14, 5541.
  14. Wu X#, Zhao W#, Wu H#, Zhang Q#, Wang Y, Yu K, Zhai J, Mo F, Wang M, Li S, Zhu X, Liang X, Hu B, Liu GH, Wu J##, Wang H##, Guo F*, Yu L*. An aggregation of human embryonic and trophoblast stem cells reveals the role of trophectoderm on epiblast differentiation. Cell Prolif. 2023, e13492.
  15. Wu H#, Luo CX#, Rong Y, Yu RX, Zhao Y, Yan L*, Wang H*, Elucidating the dynamics of polypeptide hormones in the physiological and preeclampsic placental trophoblast cells across gestation at single-cell level. Life Med. 2023, 2(3): 8.
  16. Zhai J#, Xu Y#, Wan H#, Yan R#, Guo J#, Skory R#, Yan L, Wu X, Sun F, Chen G, Zhao W, Yu K, Li W*, Guo F*, Plachta N*, Wang H*. Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture. Cell. 2023, 186(10), 2078-2091.e18. (Cover Story)
  17. Jiang X #, Zhai J #, Xiao Z#, Wu X#, Zhang D#, Wan H, Xu Y, Qi L, Wang M, Yu D, Liu Y, Wu H, Sun R, Xia S, Yu K, Guo J, Wang H*. Identifying a dynamic transcriptomic landscape of the cynomolgus macaque placenta spanning during pregnancy at single-cell resolution. Dev Cell. 2023, 58, 806-821.
  18. Jiang X#*, Wang Y#, Xiao Z, Yan L, Guo S, Wang Y, Wu H, Zhao X, Lu X*, Wang H*. A differentiation roadmap of murine placentation at single-cell resolution. Cell Discov. 2023, 9(1), 30.
  19. Zhai J#, Guo J#, Wan H#, Qi L#, Liu L#, Xiao Z, Yan L, Schmitz DA, Xu Y, Yu D, Wu X, Zhao W, Yu K, Jiang X*, Guo F*, Wu J*, Wang H*. Primate gastrulation and early organogenesis at single-cell resolution. Nature. 2022, 612(7941), 732-738.
  20. Zhou JJ#, Jiang XX#, Wu HW#, Zhang LJ, Chen M, Chen M, Shen ZM, Guo XD*, Wang H*, Gao F*, Dissecting the fate of 1 Foxl2-expressing cells in fetal ovary using lineage tracing and Single-Cell Transcriptomics. Cell Discov. 2022, 8(1), 139.
  21. Yan R#, Cheng X#, Gu C#, Xu YH#, Long X#, Zhai JL, Sun FY, Qian JJ, Du YR, Wang H*, Guo F*, Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development. Nat Genet. 2023, 55(1), 130-143.
  22. Ma J#, Liu Y#, Guo Z#, Sun R#, Yang X, Zheng W, Ma Y, Rong Y, Wang H*, Yang H*, Xiao Z*. The diversity of trophoblast cells and niches of placenta accreta spectrum disorders revealed by single-cell RNA sequencing. Front Cell Dev Biol. 2022, 10, 1044198.
  23. Gu Z#, Guo J#, Zhai J#, Feng G, Wang X, Gao Z, Li K, Ji S, Wang L, Xu Y, Chen X, Wang Y, Guo S, Yang M, Li L,Hua H, Jiang L, Wen Y, Wang L, Hao J, Li W, Wang S,* Wang H*, Gu Q*. A Uterus-Inspired Niche Drives Blastocyst Development to the Early Organogenesis. Adv Sci (Weinh). 2022, 9(28), e2202282.
  24. Tu W#, Ni D#, Yang H#, Zhao F#, Yang C#, Zhao X#, Guo Z#, Yu K, Wang J, Hu Z, Chen Z, Zhao Y, Wang Z, Gao F, Yan L*, Yang X*, Zhu L*, Wang H*. Deciphering the dynamics of the ovarian reserve in cynomolgus monkey through a quantitative morphometric study. Sci Bull. 2022, 67(18), 1854-1859.
  25. Yan L, Wang H*. Ketone bodies determine the female reproductive lifespan via regulating the ovarian reserve. Life Metab. 2022, Vol, 1, Issue 2, 101–102. (Research Highlight)
  26. Li Q#, Wu H#, Wang Y#, Wang H*, Current understanding in deciphering trophoblast cell differentiation during human placentation. Biol Reprod. 2022, 107(1), 317-326. (Invited Review)
  27. Wang Y#, Jiang X#, Jia L#, Wu X#, Wu H#, Wang Y, Li Q, Yu R, Wang H*, Xiao Z*, Liang X*. A Single-Cell Characterization of Human Post-implantation Embryos Cultured In Vitro Delineates Morphogenesis in Primary Syncytialization. Front Cell Dev Biol. 2022, 10, 835445.
  28. Wang Y#, Wu H#, Jiang X#, Jia L#, Wang M, Rong Y, Chen S, Wang Y, Xiao Z*, Liang X*, Wang H*. LMNA Determines Nuclear Morphology During Syncytialization of Human Trophoblast Stem Cells. Front Cell Dev Biol. 2022, 10, 836390.
  29. Zhai J#, Xiao Z#, Wang Y#, Wang H*. Human embryonic development: from peri-implantation to gastrulation. Trends Cell Biol. 2022, 32(1), 18-29. (Invited Review)
  30. Liang G#, Zhou C#, Jiang X#, Zhang Y, Huang B, Gao S, Kang Z, Ma D, Wang F, Gottgens B*, Wang H*, Han JJ*, Liu F*. De novo generation of macrophage from placenta-derived hemogenic endothelium. Dev Cell. 2021, 56(14), 2121-2133.
  31. Wu H#, Liao S#*, Wang Y#, Guo M#, Lin X, Wu J, Wang R, Lv D, Wu D, He M, Hu B, Long R, Peng J, Yang H, Yin H, Wang X, Huang Z, Lan K, Zhou Y, Zhang W, Xiao Z, Zhao Y*, Deng D*, Wang H*. Molecular evidence suggesting the persistence of residual SARS-CoV-2 and immune responses in the placentas of pregnant patients recovered from COVID-19. Cell Prolif. 2021, 54(9), e13091.
  32. Li X#, Wang Y#, Ma R#, Liu X, Song B, Duan Y, Guo J, Feng G, Cui T, Wang L, Hao J*, Wang H*, Gu Q*. Reconstruction of functional uterine tissues through recellularizing the decellularized rat uterine scaffolds by MSCs in vivo and in vitro. Biomed Mater. 2021, 16(3), 035023.
  33. Qu Y#, Chen Q#, Guo S#, Ma C, Lu Y, Shi J, Liu S, Zhou T, Noda T, Qian J, Zhang L, Zhu X, Lei X, Cao Y, Li W, Li W, Plachta N, Matzuk MM, Ikawa M, Duan *E, Zhang Y*, Wang H*. Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization. Protein Cell. 2021, 12(10), 810-817. (Letter)
  34. Cui D#, Liu Y#, Jiang X#, Ding C, Poon LC*, Wang H*, Yang H*. Single-cell RNA expression profiling of SARS-CoV-2-related ACE2 and TMPRSS2 in human trophectoderm and placenta. Ultrasound Obstet Gynecol. 2021, 57(2), 248-256.
  35. Zhao Y#, Ma J#, Yi P#, Wu J#, Zhao F, Tu W, Liu W, Li T, Deng Y, Hao J*, Wang H*, Yan L*. Human umbilical cord mesenchymal stem cells restore the ovarian metabolome and rescue premature ovarian insufficiency in mice. Stem Cell Res Ther. 2020, 11(1), 466.
  36. 王红梅*. 哺乳动物早期胚胎发育研究进展和伦理. 生物医学转化 2020, 1(1), 35-42.
  37. Yan L#, Wu Y#, Li L#, Wu J#, Zhao F, Gao Z, Liu W, Li T, Fan Y*, Hao J*, Liu J*, Wang H*. Clinical analysis of human umbilical cord mesenchymal stem cell allotransplantation in patients with premature ovarian insufficiency. Cell Prolif. 2020, 53(12), e12938.
  38. Xiao Z#, Yan L#, Liang X*, Wang H*. Progress in deciphering trophoblast cell differentiation during human placentation. Curr Opin Cell Biol. 2020, 67, 86-91. (Invited Review)
  39. Gao H, Liu C, Wu B, Cui H, Zhao Y, Duan Y, Gao F*, Gu Q*, Wang H*, and Li W*. Effects of Different Biomaterials and Cellular Status on Testicular Cell Self-Organization. Adv Biosyst. 2020, 4(7), e1900292.
  40. Jiang X*, Wang H*. Macrophage subsets at the maternal-fetal interface. Cell Mol Immunol. 2020, 17(8), 889-891.
  41. Guo S#, Cui X#, Jiang X#, Duo S, Li S, Gao F*, Wang H*. Tracing the origin of the placental trophoblast cells in mouse embryo development. Biol Reprod. 2020, 102(3), 598-606.
  42. Hong L#, Yan L#, Xin Z, Hao J, Liu W, Wang S, Liao S, Wang H*, Yang X*. Protective effects of human umbilical cord mesenchymal stem cell-derived conditioned medium on ovarian damage. J Mol Cell Biol. 2020, 12(5), 372-385.
  43. Ma H#, Zhai J#, Wan H#, Jiang X, Wang X, Wang L, Xiang Y, He X, Zhao ZA, Zhao B, Zheng P*, Li L*, Wang H*. In vitro culture of cynomolgus monkey embryos beyond early gastrulation. Science. 2019, 366(6467). (Featured on the cover)
  44. Wang R#, Yu R#, Zhu C, Lin HY, Lu X*, Wang H*. Tubulin detyrosination promotes human trophoblast syncytium formation. J Mol Cell Biol. 2019, 11(11), 967-978. (Cover Story)
  45. Ma J#, Wu J#, Han L, Jiang X, Yan L, Hao J*, Wang H*. Comparative analysis of mesenchymal stem cells derived from amniotic plate under serum-free condition. Stem Cell Res Ther. 2019, 10(1), 19.
  46. Jiang Y#, Yan L#, Xia L, Lu X, Zhu W, Ding D, Du M, Zhang D, Wang H*, Hu B*. Zinc finger E-box-binding homeobox 1 (ZEB1) is required for neural differentiation of human embryonic stem cells. J Biol Chem. 2018, 293(50), 19317-19329 .
  47. Wang Y, Wang H*. Successful derivation of human trophoblast stem cells. Biol Reprod. 2018, 99(2), 271-272. (Research Highlight)
  48. Liu Y#, Fan X#, Wang R#, Lu X#, Dang YL, Wang H, Lin HY, Zhu C, Ge H, Cross JC*, Wang H* Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta. Cell Res. 2018, 28(8), 819-832. (This work was highlighted in F1000)
  49. Jiang X, Du MR, Li M, Wang H*. Three macrophage subsets are identified in the uterus during early human pregnancy. Cell Mol Immunol. 2018, 15(12), 1027-1037.
  50. Chang WL#, Liu YW#, Dang YL#, Jiang XX, Xu H, Huang X, Wang YL, Wang H, Zhu C, Xue LQ, Lin HY, Meng W*, Wang H*. Plac8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration. Development. 2018, 145(2), dev148932.
  51. Lu X#, Wang R#, Zhu C, Wang H, Lin HY, Gu Y, Cross JC*, Wang H*. Fine-Tuned and Cell-Cycle-Restricted Expression of Fusogenic Protein Syncytin-2 Maintains Functional Placental Syncytia. Cell Rep. 2017, 21(5), 1150-1159.
  52. Jia Q, Cao C, Tang H, Zhang Y, Zheng Q, Wang X, Zhang R, Wang X, Luo A, Wei H, Meng A, Zhou Q*, Wang H*, Zhao J*. A 2-bp insertion (c.67_68insCC) in MC1R causes recessive white coat color in Bama miniature pigs. J Genet Genomics. 2017, 44, 215-217.
  53. Yan L#, Li Y#, Shi Z#, Lu X#, Ma J, Hu B, Jiao J*, Wang H*. The zinc finger E-box-binding homeobox 1 (Zeb1) promotes the conversion of mouse fibroblasts into functional neurons. J Biol Chem. 2017, 292(31), 12959-12970.
  54. Hai T#, Cao C#, Shang H#, Guo W#, Mu Y#, Yang S, Zhang Y, Zheng Q, Zhang T, Wang X, Liu Y, Kong Q, Li K, Wang D, Qi M, Hong Q, Zhang R, Wang X, Jia Q, Wang X, Qin G, Li Y, Luo A, Jin W, Yao J, Huang J, Zhang H, Li M, Xie X, Zheng X, Guo K, Wang Q, Zhang S, Li L, Xie F, Zhang Y, Weng X, Yin Z, Hu K, Cong Y, Zheng P, Zou H, Xin L, Xia J, Ruan J, Li H, Zhao W, Yuan J, Liu Z, Gu W, Li M, Wang Y, Wang H*, Yang S*, Liu Z*, Wei H*, Zhao J*, Zhou Q*, Meng A*. Pilot study of large-scale production of mutant pigs by ENU mutagenesis. Elife. 2017, (6), e26248.
  55. Zhang Y#, Wang Q#, Wang H*, Duan EK*. Uterine Fluid in Pregnancy: A Biological and Clinical Outlook. Trends Mol Med. 2017, 23(7), 604–614. (Invited Review)
  56. Liu D#, Mo G#, Tao Y, Wang H*, Liu XJ*. Putrescine supplementation during in vitro maturation of aged mouse oocytes improves the quality of blastocysts. Reprod Fertil Dev. 2017, 29(7), 1392-1400.
  57. 王红梅*,杜美蓉*.人类胎盘滋养层细胞的分化与妊娠相关疾病. 生命科学. 2017, 29(1), 15-20.
  58. Lu X#, Wang Y#, Yan L, Wang L, Li W, Wang H*. Variations in mesenchymal-epithelial transition-related transcription factors during reprogramming of somatic cells from different germ layers into iPSCs. J Genet Genomics. 2016, 43(10), 609-612.
  59. Cui L#, Wang H#, Lu X, Wang R, Zheng R, Li Y, Yang X, Jia WT, Zhao Y, Wang Y, Wang H, Wang YL, Zhu C, Lin HY*, Wang H*. Effects of individually silenced N-glycosylation sites and non-synonymous single-nucleotide polymorphisms on the fusogenic function of human syncytin-2. Cell Adh Migr. 2016, 10(1-2), 39-55.
  60. Nie M#, Yu S#, Peng S, Fang Y, Wang H*, Yang X*. miR-23a and miR-27a Promote Human Granulosa Cell Apoptosis by Targeting SMAD5. Biol Reprod. 2015, 93(4), 98, 1-10.
  61. Zhang Q#, Yu S#, Huang X#, Tan Y, Zhu C, Wang Y, Wang H, Lin H, Fu J*, Wang H*. New insights into the function of Cullin 3 in trophoblast invasion and migration. Reproduction. 2015, 150(2), 139-149.
  62. Lei JH#, Yang X#, Peng S#, Li Y, Underhill C, Zhu C, Lin HY*, Wang H*, Hammond GL*. Impact of corticosteroid-binding globulin deficiency on pregnancy and neonatal sex. J Clin Endocrinol Metab. 2015, 100(5), 1819-27.
  63. Chang WL#, Yang Q#, Zhang H#, Lin HY, Zhou Z, Lu X, Zhu C, Xue LQ*, Wang H*. Role of placenta-specific protein 1 in trophoblast invasion and migration. Reproduction. 2014, 148(4), 343-352.
  64. Zhou Z#, Wang R#, Yang X, Lu XY, Zhang Q, Wang YL, Wang H, Zhu C, Lin HY*, Wang H*. The cAMP-responsive element binding protein (CREB) transcription factor regulates furin expression during human trophoblast syncytialization. Placenta. 2014, 35(11), 907-18. Placenta.
  65. Wang R#, Dang YL#, Zheng R, Li Y, Li W, Lu X, Wang LJ, Zhu C, Lin HY*, Wang H*. Live cell imaging of in vitro human trophoblast syncytialization. Biol Reprod. 2014, 90(6), 117, 1-10 (Cover story).
  66. Li W, Liu D, Chang W, Lu X, Wang YL, Wang H, Zhu C, Lin HY, Zhang Y, Zhou J*, Wang H*. Role of IGF2BP3 in trophoblast cell invasion and migration. Cell Death Dis. 2014, 5(1), e1025.
  67. Aguilar PS#, Baylies MK#, Fleissner A#, Helming L#, Inoue N#, Podbilewicz B*, Wang H#, Wong M#. Genetic basis of cell–cell fusion mechanisms. Trends Genet. 2013, 29(7), 427-437. (Invited Review)
  68. Zhou Z, Zhang Q, Lu XY, Wang R, Wang H, Wang YL, Zhu C, Lin HY*, Wang H*. The proprotein convertase furin is required for trophoblast syncytialization. Cell Death Dis. 2013, 4(4), e593.
  69. Zhang Q, Chen Q, Lu XY, Zhou Z, Zhang H, Lin HY, Duan E, Zhu C, Tan Y*, Wang H*. CUL1 promotes trophoblast cell invasion at the maternal-fetal interface. Cell Death Dis. 2013, 4(2), e502.
  70. Lin HY*, Underhill C, Lei JH, Helander-Claesson A, Lee HY, Gardill BR, Muller YA, Wang H*, Hammond GL*. High frequency of SERPINA6 polymorphisms that reduce plasma corticosteroid-binding globulin activity in Chinese subjects. J Clin Endocrinol Metab. 2012, 97(4), E678-E686.
  71. Zhao KQ, Lin HY*, Zhu C, Yang X, Wang H*. Maternal Smad3 deficiency compromises decidualization in mice. J Cell Biochem. 2012, 113(10), 3266-3275.
  72. Wu L, Zhou H, Lin H, Qi J, Zhu C, Gao Z*, Wang H*. Circulating microRNAs are elevated in plasma from severe pre-eclamptic pregnancies. Reproduction. 2012, 143(3), 389-397.
  73. Yang X, Zhou Y, Peng S, Wu L, Lin HY, Wang S*, Wang H*. Differentially expressed plasma microRNAs in premature ovarian failure patients and the potential regulatory function of mir-23a in granulosa cell apoptosis. Reproduction. 2012, 144(2), 235-244.
  74. Lin P, Fu J, Zhao B, Lin F, Zou H, Liu L, Zhu C, Wang H*, Yu X*. Fbxw8 is involved in the proliferation of human choriocarcinoma JEG-3 cells. Mol Biol Rep. 2011, 38(3), 1741–1747.
  75. Fu J, Lv X, Lin H, Wu L, Wang R, Zhou Z, Zhang B, Wang YL, Tsang BK, Zhu C, Wang H*. Ubiquitin ligase cullin 7 induces epithelial-mesenchymal transition in human choriocarcinoma cells. J Biol Chem. 2010, 285(14), 10870-10879.
  76. Zhang B, Zhou Z, Lin H, Lv X, Fu J, Lin P, Zhu C, Wang H*. Protein phosphatase 1A (PPM1A) is involved in human cytotrophoblast cell invasion and migration. Histochem Cell Biol. 2009, 132(2), 169-179.
  77. Zhou Z, Shen T, Zhang BH, Lv XY, Lin HY, Zhu C, Xue LQ*, Wang H*. The proprotein convertase furin in human trophoblast: Possible role in promoting trophoblast cell migration and invasion. Placenta. 2009, 30(11), 929-938.
  78. Fu JJ, Lin P, Lv XY, Yan XJ, Wang HX, Zhu C, Tsang BK, Yu XG*, Wang H*. Low molecular mass polypeptide-2 in human trophoblast: over-expression in hydatidiform moles and possible role in trophoblast cell invasion. Placenta, 2009, 30(4), 305-312.
  79. Wang H*, Tsang BK*. Nodal signalling and apoptosis. Reproduction. 2007, 133(5), 847-853.
  80. Zhang X, Zhu C, Lin H, Yang Q, Ou Q, Li Y, Chen Z, Racey P, Zhang S*, Wang H*. Wild fulvous fruit bats (Rousettus leschenaulti) exhibit human-like menstrual cycle. Biol Reprod. 2007, 77(2), 358-364. (Cover Story)
  81. Wang H*, Jiang JY, Zhu C, Peng C, Tsang BK*. Role and regulation of nodal/activin receptor-like kinase 7 signaling pathway in the control of ovarian follicular atresia. Mol Endocrinol. 2006, 20(10), 2469-82.

其它方面介绍

主要学习经历:

  • 1991—1995 北京师范大学生物系生物学学士
  • 1995—1998 北京师范大学生物系细胞生物学硕士
  • 1999—2002 中国科学院动物研究所生理学博士

主要工作经历:

  • 1998—2006 中国科学院动物研究所研究实习员、助理研究员、副研究员
  • 2003—2005 加拿大渥太华健康研究所博士后
  • 2006—2025 中国科学院动物研究所干细胞与生殖生物学国家重点实验室(原生殖生物学国家重点实验室) 研究员
  • 2011—2017 中国科学院动物研究所干细胞与生殖生物学国家重点实验室 副主任
  • 2017—2025 中国科学院动物研究所干细胞与生殖生物学国家重点实验室 主任
  • 2024— 中国科学院动物研究所 副所长
  • 2025— 中国科学院动物研究所 器官再生与智造全国重点实验室 研究员


学会及期刊任职:

  • 2024—至今 中国生物工程学会灵长类生物医学分会 副主任委员
  • 2024—至今 载人航天工程空间应用系统空间生命科学与生物技术领域科学工作委员会 委员
  • 2024—至今 国际干细胞研究学会 (ISSCR) 会员
  • 2024—至今 国际干细胞研究学会 (ISSCR) 胚胎模型工作组成员
  • 2024—至今 Fundamental Research 编委
  • 2024—至今 Developmental Cell 编委
  • 2024—至今 Cell Stem Cell 编委
  • 2021—至今 中国生物物理学会女科学家分会(BSC女科学家分会)副秘书长
  • 2020—至今 Cell Reports Medicine 编委
  • 2019—至今 中国动物学会生殖生物学分会 主任委员
  • 2018—至今 Cell Proliferation 编委
  • 2013—至今 Biology of Reproduction 编委
  • 2016—2017 美国生殖研究学会 (SSR) 2017年年会组委会委员
  • 2001—至今 美国生殖研究学会 (SSR) 会员

获奖及荣誉:

  • 2025年度国际干细胞学会年会Anne McLaren Memorial Lecture 主旨报告人;
  • 2025年度中国科学院大学李佩优秀教师奖;
  • 2025年获得国际干细胞学会公共服务奖;
  • 2025年度北京市三八红旗奖章;
  • 2024年入选北京市科学技术奖(自然科学奖)二等奖;
  • 2024年获“中国科学院三八红旗手”称号;
  • 2023年入选“中国生命科学十大进展”;
  • 2023年获中国细胞生物学学会干细胞生物学分会,干细胞研究创新科学家奖;
  • 2023年第五届妇幼健康科学技术奖自然科学奖一等奖;
  • 2023年中国实验动物学会科学技术奖一等奖
  • 2023年度中央和国家机关“四好”党员;
  • 2021年入选人社部“万人计划”科技创新领军人才;
  • 2021年中国科学院大学教学科研工作“领雁银奖、振翅奖”;
  • 2020年度中国科学院优秀导师奖;
  • 2020年“中国科学院朱李月华优秀教师奖”;
  • 2017年中国妇幼保健协会,全国妇幼健康科学技术奖二等奖;
  • 2009年获中华人民共和国教育部自然科学奖二等奖;
  • 2004年获加拿大卫生研究院(CIHR)生殖健康科学战略培训计划奖学金;
  • 2002年获中国科学院刘永龄奖;
  • 2002年获中国台南“组织重塑:生长、凋亡与分化”研讨会优秀海报奖二等奖与三等奖

学生和其他工作人员

学术和业余活动照片


人才培养

刘素梅    硕士研究生 (2014)    首都医科大学宣武医院

黄幸    硕士研究生 (2016)    滨松光子学商贸(中国)有限公司

范强    硕士研究生 (2017)    清华大学

伊培烨    硕士研究生 (2018)    北京安诺优达基因科技有限公司

崔航    硕士研究生 (2019)    中国通用技术(集团)控股有限责任公司

陈烁    硕士研究生 (2022)    北京化学合成糖生物技术有限公司

戎音    硕士研究生 (2022)    北京烁星生物医药科技有限公司

何北佳    硕士研究生 (2024)    北京大学生命科学学院

于坤元    硕士研究生 (2024)    加利福尼亚大学洛杉矶分校

滕蔓    硕士研究生 (2025)    /

张保华    博士研究生 (2009)    加拿大渥太华大学健康研究所

付杰军    博士研究生 (2008)    Guangxi Medical University

张晓萍    博士研究生 (2007)    美国俄亥俄州立大学

李闯    博士研究生 (2010)    圣路易斯华盛顿大学

吴亮    博士研究生 (2011)    郑州大学第一附属医院

周智    博士研究生 (2011)    上海科技大学

赵坤庆    博士研究生 (2012)    北京魁飒解决方案科技有限公司

刘丹丹    博士研究生 (2015)    北京大学第三医院

吕晓寅    博士研究生 (2015)    美国得克萨斯大学安德森癌症中心

王蕊    博士研究生 (2015)    美国得克萨斯大学安德森癌症中心

崔丽娜    博士研究生 (2016)    北京安诺优达基因科技有限公司

郑茹     博士研究生 (2017)    北京安诺优达基因科技有限公司

蒋祥祥    博士研究生 (2018)    安徽医科大学

刘亚伟    博士研究生 (2018)    苏州大学

马骄    博士研究生 (2020)    北京大学第三医院

翟晶磊    博士研究生 (2020)    中国科学院动物研究所

于偌萱    博士研究生 (2020)    艾博抗(上海)贸易有限公司

郭珊珊    博士研究生 (2020)    河南工业大学

王一名    博士研究生 (2022)    北京大象生物科技有限公司

戎音    博士研究生 (2022)    北京烁星生物医药科技有限公司

赵岩    博士研究生 (2023)    北京航空航天大学医院

王越    博士研究生 (2023)    加利福尼亚大学洛杉矶分校

孙润    博士研究生 (2024)    北京博奥生物集团有限公司

夏淑薇    博士研究生 (2025)    郑州大学

蒋祥祥    博士后研究员 (2021)    安徽医科大学    国家高层次人才特殊支持计划(“万人计划”)- 青年拔尖人才

刘亚伟    博士后研究员 (2021)    苏州大学

肖振宇    博士后研究员 (2022)    北京理工大学    青年长江学者

翟晶磊    博士后研究员 (2023)    中国科学院动物研究所    国家优秀青年科学基金

吕嘉伟    博士后研究员 (2024)    中国科学院