代表性产出

代表性论文:

  1. Yang YJ , Zhang Y , Liu Q, Tian SJ , Feng WY, Deng FW, Qin GS , Wang YF * , Zhao JG* .OIVC medium enhances developmental competence in porcine preimplantation embryos. Journal of Integrative Agriculture.2025
  2. Wang X , Liu TX , Zhang Y, Xu LW ,Yuan SL ,Cui AL , Guo WW , Wang YF ,  Yang SM*,Zhao JG*.Genetically modified pigs: Emerging animal models for hereditary hearing loss.Zoological Research.2024, 45(2): 284−291
  3. Wang Z , Wang Y, Zhang Y, Qin GS , Sun WB , Wang AP, Wang YF * , Zhang GP*, Zhao JG*.On-site detection and differentiation of African swine fever virus variants using an orthogonal CRISPR-Cas12b/Cas13a-based assay.iScience.2024,27
  4. Wang XY, Wang Y, Wang Y, Guo YF, Zong RJ, Hu ST, Yue JW, Yao J, Han CS *, Guo JT*,Zhao JG*. Single-cell transcriptomic and cross-species comparison analyses reveal distinct molecular changes of porcine testes during puberty.Communications Biology. 2024,7 (1), 1478
  5. Qi YN, Zhang Y, Tian SJ, Zong RJ, Yan XH, Wang Yu, Wang YF *, Zhao JG*. An optimized prime editing system for efficient modification of the pig genome. SCIENCE CHINA Life Sciences. 2023, (66) 2851-2861
  6. Ma YJ, Wu BB, Chen YH, Ma S, Wang LY, Han TT, Lin XL, Yang FL, Liu C, Zhao JG*, Li W*. CCDC146 is required for sperm flagellum biogenesis and male fertility in mice. Cellular and Molecular Life Sciences. 2023 Dec 1;81(1):1
  7. Dong FC , Wang XG, Huang T , Yin YY, Xiao S, Ma YJ, Wei HF, Wu BB, Zhang RD, Wang LY, Guo XJ, Gao F, Liu C, Liu HB,Zhao JG*,Li W *.CCDC178-mediated cytoskeleton assembly is required for spermiogenesis in mice. Genes & Disease. 2023.09
  8. Qiao CM, He MZ, Wang SM, Jiang XJ , Wang F , Li XJ, Tan S, Chao Z, Xin WS , Gao S , Yuan JL, Li Q, Xu ZC , Zheng XL, Zhao JG*, Liu GL *.Multi-omics analysis reveals substantial linkages between the oral-gut microbiomes and inflamm-aging molecules in elderly pigs. Frontiers in Microbiology. 2023:14
  9. Zhao Y, Chen CH ,Pan JL, Lam Sin Man , Shui GH, Yang SL, Wu TW , Yang N, Tao C, Zhao JG*; Wang, YF*. Adipocyte Rnf20 ablation increases the fast-twitch fibers of skeletal muscle via lysophosphatidylcholine 16:0. Cellular and Molecular Life Science.2023:9
  10. Song R, Wang Y, Zheng Q, Yao J, Cao C, Wang Y*, Zhao JG*. One-step base editing in multiple genes by direct embryo injection for pig trait improvement. Sci China Life Sci. 2022 Ap;65(4):739-752.
  11. Gu P, Hui X, Zheng Q, Gao Y, Jin L, Jiang W, Zhou C, Liu T, Huang Y, Liu Q, Nie T, Wang Y, Wang Y, Zhao JG*, Xu A*. Mitochondrial uncoupling protein 1 antagonizes atherosclerosis by blocking NLRP3 inflammasome-dependent interleukin-1β production. Sci Adv. 2021; 7(50): eabl4024.
  12. Song R, Liu K, Wang Y, Qin G, Xiao M, Liu Y, Yang J, Zong R, Yan X, Zheng Q, Zhang H, Hou N, Yao J, Wang X, Wang Y, Zhao JG*, Zhang X*. A NCSTN heterozygous point mutation pig model simulates familial acne inversa and reveals dysregulated cholesterol biosynthesis via the notch-pAMPK-HMGCR pathway. Science Bulletin.2021, 66(23):2343-2346.
  13. Liang X, Tao C, Pan J, Zhang L, Liu L, Zhao Y, Fan Y, Cao C, Liu J, Zhang J, Lam SM, Shui G, Jin W, Li W, Zhao JG*, Li K*, Wang Y*. Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis. Protein Cell. 2021, 12(6):475-492.
  14. Liu L,Wang Y,Liang X,Wu X,Liu J,Yang S,Tao C,Zhang J,Tian J, Zhao JG*, Wang Y*. Stearoyl-CoA desaturase is essential for porcine adipocyte differentiation. Int J Mol Sci. 2020 Apr 1;21(7): E2446.
  15. Zhao JG, Lai L, Ji W, Zhou Q*. Genome editing in large animals: Current status and future prospects. Natl Sci Rev.2019, 6(3) : 402–420
  16. Hai T, Cao C, Shang H, Guo W, Mu Y, Yang S, Zhang Y, Zheng Q, Zhang T, Wang X, Liu Y, Kong Q, Li K, Wang D, Qi M, Hong Q, Zhang R, Wang X, Jia Q, Wang X, Qin G, Li Y, Luo A, Jin W, Yao J, Huang J, Zhang H, Li M, Xie X, Zheng X, Guo K, Wang Q, Zhang S, Li L, Xie F, Zhang Y, Weng X, Yin Z, Hu K, Cong Y, Zheng P, Zou H, Xin L, Xia J, Ruan J, Li H, Zhao W, Yuan J, Liu Z, Gu W, Li M, Wang Y, Wang H*, Yang S*, Liu Z*, Wei H*, Zhao JG*, Zhou Q*, Meng A*. Pilot study of large-scale production of mutant pigs by ENU mutagenesis. Elife. 2017, 6. pii: e26248.
  17. Lin J, Cao C, Tao C, Ye R, Dong M, Zheng Q, Wang C, Jiang X, Qin G, Yan C, Li K, Speakman JR, Wang Y*, Jin W*, Zhao JG*. Cold adaptation in pigs depends on UCP3 in beige adipocytes. J Mol Cell Biol. 2017 May 9.
  18. Zheng Q, Lin J, Huang J, Zhang H, Zhang R, Zhang X, Cao C, Hambly C, Qin G, Yao J, Song R, Jia Q, Wang X, Li Y, Zhang N, Piao Z, Ye R, Speakman JR, Wang H, Zhou Q, Wang Y, Jin W, Zhao JG*. Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decrease fat deposition and improve thermogenic capacity. Proc Natl Acad Sci U S A. 2017;
  19. Zhang Y, Xue Y, Cao C, Huang J, Hong Q, Hai T, Jia Q, Wang X, Qin G, Yao J, Wang X, Zheng Q, Zhang R, Li Y, Luo A, Zhang N, Shi G, Wang Y, Ying H, Liu Z, Wang H, Meng A, Zhou Q, Wei H*, Liu F*, Zhao JG*. Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis. Blood. 2017; 130(20):2161-2170.